GSoC 2025: Enhancing SBSCL with a Solver-Agnostic Layer for Constraint-Based Biological Simulation

In the past week, I integrated the Commons Math Solver into the new abstraction layer and set up the entire development environment so that everything runs stably. Progress: Built the ILPSolver interface and fully implemented the first adapter ( CommonsMathSolver ). Created a new class ( LPSolution ) to standardize result handling. Set up a demo class ( SolverDemo ) to test how the algorithm works. Challenges and Solutions: Repeated ClassNotFoundException : The main cause was a non-standard project structure, which is the default in IntelliJ. Switching to the Maven standard and synchronizing all build and run settings resolved the error. Java version conflicts : Different configurations in Maven, IntelliJ, and JAVA_HOME led to build errors. After aligning everything to Java 22 and updating the POM, the build is now stable. Status: The foundation for the abstraction layer is in place and ready for further solver integrations. The Commons Math adapter is running ...

This past week marked the transition from theoretical preparation to hands-on coding for my GSoC project. Since I have an exam coming up on Monday, my available time was a bit limited. I will resume my regular workload after that. My main focus this week was evaluating Java-based solver libraries to see how well they might integrate with SBSCL. I started by working with Apache Commons Math (specifically the SimplexSolver). I recreated minimal working examples to understand its functionality and API structure. This involved dynamically defining variables, constraints, and objective functions. Based on these tests, I was able to confirm that it's possible to dynamically map SBML-derived models to this solver’s API, which aligns perfectly with the flexibility required for SBSCL. Then I explored the ojAlgo library. Following a similliar approach as with Commons Math, I set up basic examples in Maven to try out ojAlgo's functionalities, explore its API, and see how result extraction...

Community Bonding Period - Getting Ready for SBSCL The community bonding period is coming to an end, and the actual coding phase is about to begin. Over the past two weeks, I've spent my time getting familiar with the Systems Biology Simulation Core Library (SBSCL) and preparing for my GSoC project. During this initial phase, I focused on understanding how SBSCL uses SBML (Systems Biology Markup Language) to simulate biological models. My primary interest was in constraint-based simulations, particularly Flux Balance Analysis (FBA). My project aims at enhancing SBSCL by developing a solver-agnostic framework, ensuring compatibility with different solvers and hardware platforms, including newer ARM-based systems like Apple's M-series processors. I gained deeper insight into FBA as a computational method used to calculate the optimal flow of metabolites through metabolic networks to achieve specific biological goals, such as maximizing biomass or minimizing nutrient usage. Howeve...